Digitalis toxicity.
نویسندگان
چکیده
Digitalis toxicity is a frequently encountered clinical problem. Drug interactions leading to digitalis toxicity are very common. Within this group, the interaction of digitalis and verapamil is increasingly recognized as an important cause of digitalis toxicity. The use of digoxin-binding antibodies represents a significant advance in the treatment of this problem and can be lifesaving in the setting of massive overdose. A case report of digitalis toxicity and a review of this problem and its treatment are presented.
منابع مشابه
Digitalis cardiotoxicity.
Clinical manifestations of digitalis toxicity were clearly described by Withering in 1785. One hundred years later, certain digitalis-induced arrhythmias were inscribed on the smoked drum, and shortly thereafter with the introduction of the electrocardiograph, manifestations of digitalis toxicity as recognized today were recorded in animals and human beings. With popularization of the direct-wr...
متن کاملAtrial flutter as a manifestation of digitalis toxicity.
Aklthouh digitalis is known to produce a variety otrial, junctional, (1 ventricular arihythimmias, atrial flutter due to digitalis intoxication has been rarely reported. The present paper reviews the literature and reports what appears to be the sixteenth case. The available inforimmation on the accepted cases(of atrial flutter due to digitalis toxicity has been analyzed for clues as to when di...
متن کاملElectrocardiographic manifestations: digitalis toxicity.
Toxicity from the digitalis family of cardiac glycoside medications remains common. Successful treatment depends on early recognition; however, the diagnosis of potentially life-threatening toxicity remains difficult because the clinical presentation is often nonspecific and subtle. The hallmark of cardiac toxicity is increased automaticity coupled with concomitant conduction delay. Though no s...
متن کاملInfluence of Induced Hypothermia on Digitalis Toxicity
PREVIOUS studies on the effect of digitalis on the hypothermic heart have indicated that the arrhythmic effects of hypothermia and digitalis are antagonistic. Those experiments were primarily intended to study the effect of digitalization on hypothermia using pharmacological doses of digitalis. In the experiments reported herein, the procedure was reversed in that it was thought to be of value ...
متن کاملClinical Investigation Treatment of 150 Cases of Life-Threatening Digitalis Intoxication With Digoxin-Specific Fab Antibody Fragments
One hundred fifty patients with potentially life-threatening digitalis toxicity were treated with digoxin-specific antibody fragments (Fab) purified from immunoglobulin G produced in sheep. The dose of Fab fragments was equal to the amount of digoxin or digitoxin in the patient's body as estimated from medical histories or determinations of serum digoxin or digitoxin concentrations. The younges...
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ورودعنوان ژورنال:
- The Journal of the American Board of Family Practice
دوره 2 1 شماره
صفحات -
تاریخ انتشار 1989